Description

Wolverine Stack (BPC/TB5, CJC/IPA)

Designed for the researcher interested in investigating combination vials across multiple functional classes

 

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Combo Vial: CJC-1295 No DAC/Ipamorelin

Peptide Partners Manufacturer Id: WF03

Batch Id: CI20250805

 

Combo Vial: BPC-157/TB-500

Peptide Partners Manufacturer Id: SH07

Batch Id: BB20250630

Overview

(For educational purposes only)

The “Wolverine Stack” is a popular name given to the combination protocol of BPC-157, TB-500, Ipamorelin, and CJC-1295—four peptides known for their synergistic roles in tissue repair, recovery, and regeneration. This stack draws its nickname from the fast-healing superhero because users and practitioners believe it promotes robust recovery and rapid healing following injury, surgery, or intense training.[1][2][3]

Peptide Components and Mechanisms

BPC-157 (Body Protection Compound)

BPC-157 is a synthetic pentadecapeptide derived from a naturally occurring protective protein in the stomach. It has been shown to accelerate healing of tendons, ligaments, muscles, and nerves by stimulating blood vessel growth (angiogenesis), modulating nitric oxide synthesis, increasing fibroblast migration, and reducing inflammation. BPC-157 can target the site of injury, enable collagen formation, and foster regeneration of various tissue types.[2][4][5][1]

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is the synthetic version of a region of thymosin beta-4, a protein linked with actin regulation. It promotes cell migration, reduces inflammation, and encourages tissue remodeling and repair. TB-500 works systemically, supporting healing throughout the body and aiding flexibility and recovery for muscles, soft tissue, and joints. It is often paired with BPC-157 for enhanced recovery benefits.[6][5][1][2]

Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that stimulates a pulsatile release of growth hormone (GH) from the pituitary gland without significantly raising levels of other hormones like prolactin or cortisol. By increasing GH, Ipamorelin indirectly supports tissue repair, fat loss, lean muscle maintenance, and overall recovery, especially when used with CJC-1295 for optimized hormone patterns.[7][8][2]

CJC-1295

CJC-1295 is a modified growth hormone-releasing hormone (GHRH) analog that causes a sustained increase in circulating GH and IGF-1 by prolonging GHRH’s half-life. When combined with Ipamorelin (which triggers GH pulses), CJC-1295 ensures both the amplitude and timing of GH release mimic the body’s natural rhythms. This can support muscle growth, facilitate metabolic repair, and enhance overall sleep and recovery.[9][10][2]

Typical Protocol and Synergy

A common Wolverine Stack protocol involves:

• Morning: BPC-157 (400–1000 mcg) + TB-500 (300–1000 mcg), subcutaneous injection.

• Evening: Ipamorelin (200–300 mcg) + CJC-1295 (200–300 mcg), subcutaneous injection, typically 30–60 minutes before bed.[8][9][2][7]

• Cycle: 6–12 weeks depending on goals and response.

• Administration: Morning peptides may be co-administered; evening peptides often combined in one injection.

• Purpose: Daytime healing support; nighttime hormone-optimized recovery.[2][7]

Benefits

Reported and theorized benefits of the Wolverine Stack include:

• Rapid healing of injuries (muscle strains, ligament/tendon tears, post-surgical repair)[10][3][1][2]

• Reduced inflammation, swelling, and pain with improved joint/tissue flexibility[5][1]

• Accelerated recovery from training and reduced muscle soreness

• Improved sleep quality and fat metabolism (from optimized GH pulsatility)[9][2]

• Enhanced tissue remodeling and long-term structural resilience

Important Considerations

• Experimental Use: Most evidence remains preclinical or anecdotal, with limited robust human trials on stacking combinations.[11][5]

• Safety: Monitor for adverse effects (injection reactions, water retention, joint pain) and use only under the supervision of a qualified medical provider.[8]

• Sterility: Maintain strict sterile technique and use high-quality peptides to reduce infection risk.[7][2]

The Wolverine Stack is marketed and used in sports, regenerative medicine, and anti-aging clinics for people seeking robust recovery, rapid tissue repair, and the hormonal support to optimize healing. Ongoing research into each individual peptide continues to clarify its mechanisms and clinical relevance when combined.The “Wolverine Stack” is a popular peptide combination protocol designed to enhance soft tissue healing, accelerate recovery from injuries, and promote overall regeneration by leveraging the synergistic effects of four different peptides: BPC-157, TB-500, Ipamorelin, and CJC-1295. BPC-157 and TB-500 are often considered the foundation of this stack for localized and systemic repair, respectively—BPC-157 targets damaged tissue sites and accelerates tendon, ligament, and muscle regeneration, while TB-500 helps with cell migration, inflammation reduction, and broad tissue remodeling throughout the body.[3][1][5][2]

Added to this foundation are the growth hormone secretagogues CJC-1295 (a GHRH analog) and Ipamorelin (a selective GHRP), which together increase natural growth hormone and IGF-1 via both sustained and pulsatile release patterns—supporting muscle anabolism, reducing recovery times, and potentially improving sleep quality. Typical protocols call for daily morning administration of BPC-157 (400–1000 mcg) and TB-500 (300–1000 mcg), with CJC-1295 (200–300 mcg) and Ipamorelin (200–300 mcg) given together in the evening, subcutaneously.[9][2][7][8]

Athletes and clinics report that this combination can help close wounds faster, reduce swelling and pain, improve joint mobility, and shorten downtime after strains, sprains, or surgery. The full stack is most often cycled for 6–12 weeks and is used by those seeking a powerful boost to the body’s self-healing mechanisms—though it is experimental, with limited human clinical data supporting the combined protocol to date. Proper sterile technique, medical oversight, and sourcing from reputable suppliers are essential for safety with these peptide stacks.[5][11][3][2][7][8]

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1. https://www.dellabellezzamedspa.com/blog/what-is-the-wolverine-stack-for-healing-injuries-and-the-body      

2. https://www.peptidescience.academy/post/the-complete-stack-bpc-157-tb-500-cjc-1295-and-ipamorelin             

3. https://pathwayhealthandbeauty.com/peptides-+-peptide-stacks    

4. https://pmc.ncbi.nlm.nih.gov/articles/PMC6271067/ 

5. https://zone.health/peptides/protocols/      

6. https://ourfamilyhealthcenter.com/blog/wolverine-stack-peptide-therapy/ 

7. https://swolverine.com/blogs/blog/ipamorelin-dosage-guide-optimal-protocols-for-recovery-and-muscle-growth      

8. https://www.poseidonperformance.com/blog/essential-guide-to-peptide-dosages-how-to-safely-optimize-your-results     

9. https://swolverine.com/blogs/blog/the-best-peptides-for-recovery-bpc-157-tb500-mk-677-ipamorelin-cjc-1295-and-more    

10. https://desertwellnesscenter.com/2023/09/how-to-take-peptides/  

11. https://theconversation.com/peptides-performance-boosting-anti-ageing-drugs-or-dangerous-snake-oil-259531  

12. https://www.youtube.com/watch?v=OfcexE9s4yw 

13. https://swolverine.com/blogs/blog/bpc-157-vs-mk-677-cjc-1295-and-tb-500-which-peptide-is-right-for-recovery-and-performance 

14. https://www.instagram.com/reel/DMF-oalxZ3x/ 

15. https://www.orthopedicsri.com/blog-items/the-wolverine-drug/ 

16. https://montecitoconciergemedicine.com/we-provide/peptide-therapy/ 

17. https://www.iowaiv.com/blog/breakthrough-peptide-healing-how-bpc-157-tb-500-support-rapid-recovery-at-iowa-iv 

18. https://thereclinic.com/what-is-the-wolverine-blend-peptide-and-why-are-women-talking-about-it/ 

19. https://www.mcgill.ca/oss/article/critical-thinking-health-and-nutrition/human-lab-rats-injecting-themselves-peptides 

20. https://podcasts.apple.com/us/podcast/the-wolverine-peptide-stack-rebuild-recover-and/id1497651187?i=1000711847800&l=pt-BR